Wash your hands well with soap and warm water for at least 20 seconds.
Heat large pot over medium high heat and cook beef until no longer pink, about 5 minutes. Drain beef in a colander and return to pot.
Add tomato sauce, water, Italian seasoning, and garlic powder. Stir and bring to a boil.
Add noodles to the pot, stir, and reduce heat to medium. Cover and cook for 5 minutes.
Drain thawed spinach and add to pot and stir. If mixture is too thick or sticking to the pot, add more water, about a cup. Cover and cook for 5 more minutes.
Spread cottage cheese over top of beef, noodle, and spinach mixture and sprinkle with mozzarella cheese. Reduce heat to low and cover for about 10 minutes to melt cheese.